Substrate: Double strand break repair protein MRE11A (Deoxyribonuclease)
Seq-ID: P49959 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7231003   RAD50_HUMAN
MINT-7906697   FACD2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
manganese ion binding,
single-stranded DNA specific endodeoxyribonuclease activity,
protein C-terminus binding,
3`-5` exonuclease activity,
double-stranded DNA binding		 nucleoplasm,
Mre11 complex		 double-strand break repair via nonhomologous end joining,
reciprocal meiotic recombination,
negative regulation of DNA endoreduplication,
positive regulation of kinase activity,
regulation of mitotic recombination,
DNA duplex unwinding,
telomere maintenance via telomerase,
positive regulation of protein amino acid autophosphorylation,
sister chromatid cohesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 74 ENKPSRKTLHTCLELLRKYCM - 15302935
HTP
0.24
 - Metallophos
0.16
 - medium
S 264 TKNEQQLFYISQPGSSVVTSL ATM 10608806
LTP
0.25
 MOD_PIKK_1
 - Mre11_DNA_bind
0.35
 - medium
S 558 IDLAEQMANDSDDSISAATNK - 18669648
HTP
0.19
 - -
0.74
 - medium
S 649 NYSEVIEVDESDVEEDIFPTT - 15845385
LTP
0.22
 - -
0.64
 - medium
S 649 NYSEVIEVDESDVEEDIFPTT - 18669648
HTP
0.22
 - -
0.64
 - medium
S 678 STSSSKIMSQSQVSKGVDFES - 17525332
HTP
0.97
 - -
0.68
 - medium
S 688 SQVSKGVDFESSEDDDDDPFM - 15302935
HTP
0.27
 - -
0.76
 - medium
S 688 SQVSKGVDFESSEDDDDDPFM - 16083285
HTP
0.27
 - -
0.76
 - medium
S 688 SQVSKGVDFESSEDDDDDPFM - 17081983
HTP
0.27
 - -
0.76
 - medium
S 688 SQVSKGVDFESSEDDDDDPFM - 18669648
HTP
0.27
 - -
0.76
 - medium
S 689 QVSKGVDFESSEDDDDDPFMN - 15302935
HTP
0.76
 - -
0.74
 - medium
S 689 QVSKGVDFESSEDDDDDPFMN - 16083285
HTP
0.76
 - -
0.74
 - medium
S 689 QVSKGVDFESSEDDDDDPFMN - 17081983
HTP
0.76
 - -
0.74
 - medium
S 689 QVSKGVDFESSEDDDDDPFMN - 18669648
HTP
0.76
 - -
0.74
 - medium
S 701 DDDDDPFMNTSSLRRNRR    - 18669648
HTP
0.82
 - -
0.78
 - medium
S 702 DDDDPFMNTSSLRRNRR     - 18669648
HTP
0.69
 - -
0.77
 - medium

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